The Endocannabinoid System

The proper functioning of the body and its ability to attain and maintain homeostasis and regulate different body functions is a complex process that is realized through the endocannabinoid system (the ECS). The ECS is a complex network of endocannabinoids (natural chemical compounds found in cannabis), receptors that transport signals from various parts of the body and bond with the endocannabinoids, and the enzymes that process the cannabinoids and endocannabinoids. The proper functioning of the body is dependent on the effective functioning of the ECS.

How Does Endocannabinoid System Work?

The endocannabinoid system is very important as it helps the body reach and sustain homeostasis by continually ensuring the stability of internal body activities irrespective of the changes in external factors. This helps realize the right hormone levels of the body, temperature, mood, and sleep, among others. Whenever there is an imbalance, the ECS is activated to restore balance. That is why you will naturally start sweating if the external environment is hot as a restoration mechanism of the body to get rid of the excess heat.

Experts argue that the body relies on endocannabinoid receptors to pick up the signals from various parts of the body and transport them to the brain to trigger a response. Two main receptors are critical for this; the CB1 receptors in the central nervous system and the CB2 receptors found outside the nervous system, such as the immune and digestive systems.

Note that the ECS mainly operates on demand to respond to specific stimuli. Its effect on one system of the body may not affect another. For example, an action on the reproductive system will trigger the ECS to regulate the right hormones without affecting the immune or digestive system.

After restoring the right balance, the enzymes will be activated to break them down and maintain the required balance needed by the body. Two main enzymes help break down the endocannabinoids: the fatty acid amide hydrolase, which helps break down the anandamide and monoacylglycerol acid lipase, which acts on the 2-arachidonoylglycerol(2-AG).

What are the Main Functions of the ECS

Main Functions of the ECS

Through the above process, the ECS enables the body to regulate various body functions essential for the overall well-being of a person. Some of them include:

  • Appetite and digestion.
  • The immune system helps one fight diseases and infections.
  • Inflammation.
  • Mood, anxiety, and depression.
  • Fertility and reproduction system.
  • Pain.
  • Body temperature.
  • Motor control.
  • Memory.

Scientists believe that the ECS has a role in everybody’s activity. Making it one of the most important body systems.

How Does CBD Interact With the ECS?

Even though the exact interaction of CBD with the ECS is still debatable, there is sufficient evidence that shows that the therapeutic benefits of CBD is derived from its ability to bind with the ECS receptors. This helps hasten the transfer of signals from the external environment to the brain for faster response to restore balance.

It is also believed that it helps with endocannabinoid deficiency by inhibiting the fatty acid amide hydrolase (FAAH) that processes endocannabinoids. It is important to note that the action of CBD and THC may vary based on other factors such as the condition and dosage.

Endocannabinoid Deficiency

The ECS is structured so that it only springs into action when needed. The failure of the body to regulate the normal functions requisite to its well-being may lead to endocannabinoid deficiency. Even though it is not considered a disease, the deficiency may cause other conditions such as migraine, fibromyalgia, and irritable bowel syndrome. Sadly, these syndromes or conditions are usually nonreceptive to treatments unless proper functioning of the ECS is restored.

In as much as the correct measure of endocannabinoid deficiency is unknown, experts recommend that continued use of CBD and cannabis is the surest way as it also helps attend to various medical conditions that the deficiency may cause. Doing this can help manage medical conditions such as cardiovascular complications, Alzheimer’s disease, acute and chronic kidney disease, pain, autoimmune diseases and inflammatory conditions.

Some of the common remedies for endocannabinoid deficiency include:

  • Consuming foods and supplements rich in omega-3 fatty acids.
  • Avoid excessive alcohol consumption to allow prompt repair of endocannabinoid receptors.
  • Regular exercises and physical activities keep the body in the best working condition.

Even though the above may help, the ultimate remedy to endocannabinoid deficiency is to consume CBD, either directly or indirectly, through CBD-infused food or supplements.


The endocannabinoid system is critical for the well-being of every individual. Guaranteed performance can be attained by consuming CBD oil, as it will also help keep some ailments at bay. Since CBD oil with less than 0.3% THC content is legal in the United States, you can always consider reputable CBD brands to always boost the functioning of the endocannabinoid system. Remember, always consult your doctor for guidance.

Leave a Reply

Your email address will not be published. Required fields are marked *

Skip to content